Drug interactions
Etravirine + Voriconazole
Severity: Moderate
Etravirine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases etravirine exposure, while etravirine, an inducer of CYP enzymes, may lower voriconazole concentrations. Etravirine is also a CYP2C19 substrate, so the interaction runs in both directions.
What this interaction means in plain words
Etravirine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C19/CYP3A4 metabolism of etravirine, while etravirine induces voriconazole metabolism.
What to do
Monitor voriconazole trough levels and clinical antifungal response. Watch for etravirine adverse effects such as rash.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Voriconazole?
MediHelp rates the interaction as moderate. Etravirine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole increases etravirine exposure, while etravirine, an inducer of CYP enzymes, may lower voriconazole concentrations. Etravirine is also a CYP2C19 substrate, so the interaction runs in both directions.
How serious is the interaction between Etravirine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough levels and clinical antifungal response. Watch for etravirine adverse effects such as rash.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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