Drug interactions
Everolimus + Isavuconazonium
Severity: Moderate
Everolimus and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety, is a moderate CYP3A4 inhibitor and P-gp inhibitor and can raise everolimus concentrations. This increases the risk of everolimus toxicity such as mucositis, infection and hyperlipidemia.
What this interaction means in plain words
Everolimus and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Isavuconazonium belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by isavuconazole reduces everolimus clearance.
What to do
Monitor everolimus trough concentrations and adverse effects, and reduce the dose as required while on isavuconazonium. Readjust the dose after the antifungal is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Everolimus with Isavuconazonium?
MediHelp rates the interaction as moderate. Everolimus and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety, is a moderate CYP3A4 inhibitor and P-gp inhibitor and can raise everolimus concentrations. This increases the risk of everolimus toxicity such as mucositis, infection and hyperlipidemia.
How serious is the interaction between Everolimus and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and adverse effects, and reduce the dose as required while on isavuconazonium. Readjust the dose after the antifungal is discontinued.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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