Drug interactions
Everolimus + Rifapentine
Severity: Major
Everolimus and Rifapentine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an inducer of CYP3A4 and can substantially lower everolimus blood concentrations. This may lead to loss of efficacy, such as transplant rejection or tumour progression.
What this interaction means in plain words
Everolimus and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Everolimus belongs to Oncology; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4 (and likely P-glycoprotein), increasing the metabolism and efflux of everolimus.
What to do
Avoid the combination where possible and choose an alternative antimycobacterial agent. If it cannot be avoided, increase the everolimus dose per labeling and monitor trough levels, then readjust after rifapentine is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Everolimus with Rifapentine?
MediHelp rates the interaction as major. Everolimus and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifapentine is an inducer of CYP3A4 and can substantially lower everolimus blood concentrations. This may lead to loss of efficacy, such as transplant rejection or tumour progression.
How serious is the interaction between Everolimus and Rifapentine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antimycobacterial agent. If it cannot be avoided, increase the everolimus dose per labeling and monitor trough levels, then readjust after rifapentine is stopped.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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