Drug interactions
Everolimus + Saxagliptin-metformin
Severity: Moderate
Everolimus and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus commonly causes hyperglycemia and hyperlipidemia, which may counteract the effect of glucose-lowering therapy. Patients with diabetes may need treatment intensification.
What this interaction means in plain words
Everolimus and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
mTOR inhibition reduces insulin signaling and increases insulin resistance, opposing antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c before and during everolimus therapy and intensify antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Everolimus and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus commonly causes hyperglycemia and hyperlipidemia, which may counteract the effect of glucose-lowering therapy. Patients with diabetes may need treatment intensification.
How serious is the interaction between Everolimus and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c before and during everolimus therapy and intensify antidiabetic treatment as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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