Drug interactions
Everolimus + Ustekinumab
Severity: Moderate
Everolimus and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is an mTOR inhibitor with immunosuppressive activity. Combined with ustekinumab it may raise infection risk.
What this interaction means in plain words
Everolimus and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression through mTOR inhibition and IL-12/23 blockade.
What to do
Monitor for signs of infection and review the need for both agents. Avoid if an alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Ustekinumab?
MediHelp rates the interaction as moderate. Everolimus and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus is an mTOR inhibitor with immunosuppressive activity. Combined with ustekinumab it may raise infection risk.
How serious is the interaction between Everolimus and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and review the need for both agents. Avoid if an alternative exists.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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