Drug interactions
Everolimus + Voclosporin
Severity: Major
Everolimus and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can impair renal function, and combining a calcineurin inhibitor with an mTOR inhibitor can increase nephrotoxicity. Voclosporin may also raise everolimus exposure, and the combination adds immunosuppression and infection risk.
What this interaction means in plain words
Everolimus and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Everolimus belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity and immunosuppression; calcineurin inhibitors can also increase everolimus exposure via CYP3A4 and P-gp inhibition.
What to do
Avoid concurrent use if possible. If it is necessary, monitor serum creatinine, eGFR and everolimus trough levels closely and reduce doses as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Everolimus with Voclosporin?
MediHelp rates the interaction as major. Everolimus and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can impair renal function, and combining a calcineurin inhibitor with an mTOR inhibitor can increase nephrotoxicity. Voclosporin may also raise everolimus exposure, and the combination adds immunosuppression and infection risk.
How serious is the interaction between Everolimus and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible. If it is necessary, monitor serum creatinine, eGFR and everolimus trough levels closely and reduce doses as needed.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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