Drug interactions
Everolimus + Vonoprazan
Severity: Minor
Everolimus and Vonoprazan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A4 inhibitor and may slightly raise everolimus concentrations. The effect is expected to be small.
What this interaction means in plain words
Everolimus and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Everolimus belongs to Oncology; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP3A4 reduces everolimus metabolism.
What to do
Monitor everolimus trough levels and for adverse effects during coadministration. Adjust the everolimus dose only if levels rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Everolimus with Vonoprazan?
MediHelp rates the interaction as minor. Everolimus and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vonoprazan is a weak CYP3A4 inhibitor and may slightly raise everolimus concentrations. The effect is expected to be small.
How serious is the interaction between Everolimus and Vonoprazan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels and for adverse effects during coadministration. Adjust the everolimus dose only if levels rise.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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