Drug interactions
Everolimus + Voxelotor
Severity: Moderate
Everolimus and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and increase exposure to sensitive substrates such as everolimus. Higher everolimus levels may cause more infections, mucositis, hyperglycemia and pneumonitis.
What this interaction means in plain words
Everolimus and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing everolimus metabolism.
What to do
Monitor everolimus trough concentrations and adverse effects, and reduce the everolimus dose if levels are high. Consider an alternative if exposure cannot be controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Everolimus with Voxelotor?
MediHelp rates the interaction as moderate. Everolimus and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can inhibit CYP3A4 and increase exposure to sensitive substrates such as everolimus. Higher everolimus levels may cause more infections, mucositis, hyperglycemia and pneumonitis.
How serious is the interaction between Everolimus and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and adverse effects, and reduce the everolimus dose if levels are high. Consider an alternative if exposure cannot be controlled.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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