Drug interactions
Ezetimibe + Fenofibrate micronized
Severity: Minor
Ezetimibe and Fenofibrate micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate can modestly increase total ezetimibe concentrations, and ezetimibe may increase biliary cholesterol excretion and raise gallstone risk with fibrates. The pharmacokinetic change is small and the combination is commonly used.
What this interaction means in plain words
Ezetimibe and Fenofibrate micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The pharmacokinetic mechanism is not clearly established; fibrates also increase biliary cholesterol excretion.
What to do
Combination is acceptable; if cholelithiasis is suspected, evaluate gallbladder and consider stopping the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Frequently asked questions
Can I take Ezetimibe with Fenofibrate micronized?
MediHelp rates the interaction as minor. Ezetimibe and Fenofibrate micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate can modestly increase total ezetimibe concentrations, and ezetimibe may increase biliary cholesterol excretion and raise gallstone risk with fibrates. The pharmacokinetic change is small and the combination is commonly used.
How serious is the interaction between Ezetimibe and Fenofibrate micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combination is acceptable; if cholelithiasis is suspected, evaluate gallbladder and consider stopping the combination.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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