Drug interactions
Ezetimibe + Sofosbuvir / velpatasvir
Severity: Moderate
Ezetimibe and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits several hepatic uptake transporters and may increase ezetimibe exposure. The effect is expected to be modest, but it could increase dose-related adverse effects.
What this interaction means in plain words
Ezetimibe and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits OATP1B1, OATP1B3 and OATP2B1, decreasing transporter-mediated uptake of ezetimibe.
What to do
Monitor for muscle symptoms and hepatic enzyme elevations during the HCV treatment course. No empirical dose change is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Frequently asked questions
Can I take Ezetimibe with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Ezetimibe and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits several hepatic uptake transporters and may increase ezetimibe exposure. The effect is expected to be modest, but it could increase dose-related adverse effects.
How serious is the interaction between Ezetimibe and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and hepatic enzyme elevations during the HCV treatment course. No empirical dose change is required.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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