Drug interactions
Famotidine + Pretomanid
Severity: Minor
Famotidine and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OAT3 in vitro, and famotidine is renally secreted partly through OAT3. Famotidine exposure could rise, though clinical significance is uncertain.
What this interaction means in plain words
Famotidine and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of renal OAT3-mediated tubular secretion of famotidine by pretomanid.
What to do
Monitor for famotidine adverse effects such as headache, dizziness or confusion, particularly in renal impairment, and reduce the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Famotidine
Other interactions of Pretomanid
Frequently asked questions
Can I take Famotidine with Pretomanid?
MediHelp rates the interaction as minor. Famotidine and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OAT3 in vitro, and famotidine is renally secreted partly through OAT3. Famotidine exposure could rise, though clinical significance is uncertain.
How serious is the interaction between Famotidine and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for famotidine adverse effects such as headache, dizziness or confusion, particularly in renal impairment, and reduce the dose if needed.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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