Drug interactions
Fedratinib + Flecainide
Severity: Moderate
Fedratinib and Flecainide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6 and may increase flecainide exposure. Raised flecainide levels increase the risk of conduction disturbances and arrhythmia.
What this interaction means in plain words
Fedratinib and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Flecainide belongs to Cardiovascular.
Why it happens
Fedratinib inhibits CYP2D6, reducing flecainide metabolism.
What to do
Monitor ECG and flecainide levels when fedratinib is started. Reduce the flecainide dose if conduction intervals lengthen or toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Flecainide?
MediHelp rates the interaction as moderate. Fedratinib and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6 and may increase flecainide exposure. Raised flecainide levels increase the risk of conduction disturbances and arrhythmia.
How serious is the interaction between Fedratinib and Flecainide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and flecainide levels when fedratinib is started. Reduce the flecainide dose if conduction intervals lengthen or toxicity occurs.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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