Drug interactions
Fedratinib + Fluoxetine
Severity: Moderate
Fedratinib and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is cleared by CYP3A4 and CYP2C19, and fluoxetine inhibits CYP2C19 and, to a lesser extent, CYP3A4. This may raise fedratinib exposure and increase the risk of toxicity such as gastrointestinal effects, anemia and encephalopathy. Fluoxetine is also a moderate CYP2D6 inhibitor-relevant substrate interaction since fedratinib inhibits CYP2D6.
What this interaction means in plain words
Fedratinib and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Fluoxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 and CYP3A4 by fluoxetine may reduce fedratinib metabolism.
What to do
Monitor for fedratinib toxicity, including blood counts and neurological symptoms. Consider reducing the fedratinib dose or choosing a different antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fluoxetine?
MediHelp rates the interaction as moderate. Fedratinib and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is cleared by CYP3A4 and CYP2C19, and fluoxetine inhibits CYP2C19 and, to a lesser extent, CYP3A4. This may raise fedratinib exposure and increase the risk of toxicity such as gastrointestinal effects, anemia and encephalopathy. Fluoxetine is also a moderate CYP2D6 inhibitor-relevant substrate interaction since fedratinib inhibits CYP2D6.
How serious is the interaction between Fedratinib and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fedratinib toxicity, including blood counts and neurological symptoms. Consider reducing the fedratinib dose or choosing a different antidepressant.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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