Drug interactions
Fedratinib + Flutamide
Severity: Moderate
Fedratinib and Flutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may raise flutamide exposure. Flutamide is hepatotoxic, and flutamide is metabolized by CYP1A2 as well as other pathways, so the effect is uncertain but plausible.
What this interaction means in plain words
Fedratinib and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Flutamide belongs to Endocrine.
Why it happens
Fedratinib inhibits CYP3A4, potentially reducing flutamide metabolism.
What to do
Monitor liver function tests regularly and watch for flutamide adverse effects. Consider stopping flutamide if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Flutamide?
MediHelp rates the interaction as moderate. Fedratinib and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may raise flutamide exposure. Flutamide is hepatotoxic, and flutamide is metabolized by CYP1A2 as well as other pathways, so the effect is uncertain but plausible.
How serious is the interaction between Fedratinib and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly and watch for flutamide adverse effects. Consider stopping flutamide if transaminases rise.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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