Drug interactions
Fedratinib + Fluticasone-vilanterol
Severity: Moderate
Fedratinib and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can raise exposure to CYP3A4 substrates. Both fluticasone furoate and vilanterol are CYP3A4 substrates, so systemic corticosteroid effects and beta-agonist cardiovascular effects could increase.
What this interaction means in plain words
Fedratinib and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fluticasone furoate and vilanterol.
What to do
Monitor for tachycardia, tremor, hypokalemia and signs of systemic corticosteroid excess during prolonged use. Consider an alternative inhaler if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fedratinib and Fluticasone-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Fedratinib and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can raise exposure to CYP3A4 substrates. Both fluticasone furoate and vilanterol are CYP3A4 substrates, so systemic corticosteroid effects and beta-agonist cardiovascular effects could increase.
How serious is the interaction between Fedratinib and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, tremor, hypokalemia and signs of systemic corticosteroid excess during prolonged use. Consider an alternative inhaler if adverse effects develop.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
