Drug interactions
Fedratinib + Fluticasone
Severity: Moderate
Fedratinib and Fluticasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase fluticasone exposure. The risk of systemic corticosteroid effects increases with long-term or high-dose use.
What this interaction means in plain words
Fedratinib and Fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Fluticasone belongs to Respiratory.
Why it happens
Fedratinib inhibits CYP3A4, reducing fluticasone clearance.
What to do
Monitor for systemic corticosteroid effects during long-term use. Consider switching to beclomethasone if prolonged coadministration is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fluticasone?
MediHelp rates the interaction as moderate. Fedratinib and Fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase fluticasone exposure. The risk of systemic corticosteroid effects increases with long-term or high-dose use.
How serious is the interaction between Fedratinib and Fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects during long-term use. Consider switching to beclomethasone if prolonged coadministration is required.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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