Drug interactions
Fedratinib + Hydrochlorothiazide-losartan
Severity: Minor
Fedratinib and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The warning concerns dual CYP3A4 and CYP2C19 inhibitors, and losartan is not such an inhibitor. A clinically important rise in fedratinib exposure is not expected.
What this interaction means in plain words
Fedratinib and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
No established pharmacokinetic mechanism; losartan is not a recognised inhibitor of CYP3A4 or CYP2C19.
What to do
No dose adjustment is required; monitor for fedratinib toxicity including gastrointestinal effects and anaemia as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Fedratinib and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The warning concerns dual CYP3A4 and CYP2C19 inhibitors, and losartan is not such an inhibitor. A clinically important rise in fedratinib exposure is not expected.
How serious is the interaction between Fedratinib and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for fedratinib toxicity including gastrointestinal effects and anaemia as usual.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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