Drug interactions
Fedratinib + Hydrocodone
Severity: Moderate
Fedratinib and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate inhibitor of CYP3A4 and can raise hydrocodone exposure, since hydrocodone is cleared mainly by CYP3A4. Higher hydrocodone levels may intensify sedation and respiratory depression.
What this interaction means in plain words
Fedratinib and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Hydrocodone belongs to Musculoskeletal.
Why it happens
Fedratinib inhibits CYP3A4-mediated N-demethylation of hydrocodone, reducing its clearance.
What to do
Monitor for sedation and respiratory depression when starting fedratinib in a patient on hydrocodone, and reduce the opioid dose if needed. If fedratinib is stopped, reassess opioid effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Hydrocodone?
MediHelp rates the interaction as moderate. Fedratinib and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate inhibitor of CYP3A4 and can raise hydrocodone exposure, since hydrocodone is cleared mainly by CYP3A4. Higher hydrocodone levels may intensify sedation and respiratory depression.
How serious is the interaction between Fedratinib and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression when starting fedratinib in a patient on hydrocodone, and reduce the opioid dose if needed. If fedratinib is stopped, reassess opioid effect.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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