Drug interactions
Fedratinib + Imatinib
Severity: Moderate
Fedratinib and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may increase fedratinib exposure, since fedratinib is cleared by CYP3A4 and CYP2C19. Higher fedratinib levels raise the risk of gastrointestinal toxicity, anemia and encephalopathy including Wernicke's.
What this interaction means in plain words
Fedratinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of fedratinib.
What to do
Monitor for fedratinib toxicity and thiamine status; reduce the fedratinib dose per labeling for CYP3A4 inhibitors if the combination is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Imatinib?
MediHelp rates the interaction as moderate. Fedratinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and may increase fedratinib exposure, since fedratinib is cleared by CYP3A4 and CYP2C19. Higher fedratinib levels raise the risk of gastrointestinal toxicity, anemia and encephalopathy including Wernicke's.
How serious is the interaction between Fedratinib and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fedratinib toxicity and thiamine status; reduce the fedratinib dose per labeling for CYP3A4 inhibitors if the combination is required.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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