Drug interactions
Fedratinib + Linagliptin-metformin
Severity: Moderate
Fedratinib and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase linagliptin exposure. Fedratinib also inhibits OCT2 and MATE1/2-K, which could raise metformin concentrations.
What this interaction means in plain words
Fedratinib and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Linagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 raises linagliptin levels, and inhibition of OCT2/MATE transporters reduces renal metformin clearance.
What to do
Monitor for metformin adverse effects, including gastrointestinal intolerance and signs of lactic acidosis, and check renal function; no empiric linagliptin adjustment is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Fedratinib and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase linagliptin exposure. Fedratinib also inhibits OCT2 and MATE1/2-K, which could raise metformin concentrations.
How serious is the interaction between Fedratinib and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin adverse effects, including gastrointestinal intolerance and signs of lactic acidosis, and check renal function; no empiric linagliptin adjustment is needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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