Drug interactions
Fedratinib + Metaxalone
Severity: Moderate
Fedratinib and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and may raise metaxalone concentrations. Higher exposure could increase sedation, dizziness and other dose-related adverse effects.
What this interaction means in plain words
Fedratinib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Fedratinib inhibits CYP3A4, reducing the metabolic clearance of metaxalone.
What to do
Monitor for increased drowsiness and dizziness and consider a lower metaxalone dose while fedratinib is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Metaxalone?
MediHelp rates the interaction as moderate. Fedratinib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and may raise metaxalone concentrations. Higher exposure could increase sedation, dizziness and other dose-related adverse effects.
How serious is the interaction between Fedratinib and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and dizziness and consider a lower metaxalone dose while fedratinib is given.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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