Drug interactions
Fedratinib + Nebivolol
Severity: Moderate
Fedratinib and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6, the main enzyme metabolizing nebivolol, and can raise nebivolol exposure. This may lead to bradycardia and hypotension.
What this interaction means in plain words
Fedratinib and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Nebivolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated nebivolol metabolism by fedratinib.
What to do
Monitor heart rate and blood pressure when starting fedratinib. Reduce the nebivolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Nebivolol?
MediHelp rates the interaction as moderate. Fedratinib and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6, the main enzyme metabolizing nebivolol, and can raise nebivolol exposure. This may lead to bradycardia and hypotension.
How serious is the interaction between Fedratinib and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting fedratinib. Reduce the nebivolol dose if bradycardia or hypotension occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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