Drug interactions
Fedratinib + Propafenone
Severity: Moderate
Fedratinib and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP2D6 inhibitor and can increase propafenone exposure. This may cause conduction slowing, bradycardia and proarrhythmia, particularly in patients already taking CYP3A4 inhibitors.
What this interaction means in plain words
Fedratinib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6 by fedratinib reduces propafenone metabolism.
What to do
Monitor ECG and heart rate, and reduce the propafenone dose if conduction changes or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Propafenone?
MediHelp rates the interaction as moderate. Fedratinib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP2D6 inhibitor and can increase propafenone exposure. This may cause conduction slowing, bradycardia and proarrhythmia, particularly in patients already taking CYP3A4 inhibitors.
How serious is the interaction between Fedratinib and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, and reduce the propafenone dose if conduction changes or adverse effects occur.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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