Drug interactions
Fedratinib + Quinidine
Severity: Moderate
Fedratinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib moderately inhibits CYP3A4 and also inhibits CYP2D6, so quinidine exposure may rise. Because quinidine has a narrow therapeutic index, higher levels can increase QT prolongation and arrhythmia risk.
What this interaction means in plain words
Fedratinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Fedratinib inhibits CYP3A4 metabolism of quinidine.
What to do
Monitor ECG/QTc and quinidine levels, and reduce the quinidine dose if exposure rises or QTc lengthens. Check electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Quinidine?
MediHelp rates the interaction as moderate. Fedratinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib moderately inhibits CYP3A4 and also inhibits CYP2D6, so quinidine exposure may rise. Because quinidine has a narrow therapeutic index, higher levels can increase QT prolongation and arrhythmia risk.
How serious is the interaction between Fedratinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG/QTc and quinidine levels, and reduce the quinidine dose if exposure rises or QTc lengthens. Check electrolytes.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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