Drug interactions
Fedratinib + Regorafenib
Severity: Moderate
Fedratinib and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase regorafenib plasma concentrations. Higher regorafenib exposure raises the risk of hepatotoxicity, hypertension and hand-foot skin reaction.
What this interaction means in plain words
Fedratinib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4-mediated metabolism of regorafenib.
What to do
Monitor liver function, blood pressure and skin toxicity, and reduce the regorafenib dose if adverse effects emerge. Consider an alternative to fedratinib if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Regorafenib?
MediHelp rates the interaction as moderate. Fedratinib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase regorafenib plasma concentrations. Higher regorafenib exposure raises the risk of hepatotoxicity, hypertension and hand-foot skin reaction.
How serious is the interaction between Fedratinib and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function, blood pressure and skin toxicity, and reduce the regorafenib dose if adverse effects emerge. Consider an alternative to fedratinib if feasible.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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