Drug interactions
Fedratinib + Roflumilast
Severity: Moderate
Fedratinib and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can raise exposure to roflumilast and its active N-oxide metabolite. Higher exposure may increase PDE4-related adverse effects such as diarrhea, nausea, weight loss, insomnia, headache and psychiatric symptoms.
What this interaction means in plain words
Fedratinib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Roflumilast belongs to Respiratory.
Why it happens
Fedratinib inhibits CYP3A4, reducing the metabolism of roflumilast.
What to do
Monitor for gastrointestinal, weight, sleep and mood adverse effects of roflumilast during co-therapy. Consider stopping roflumilast if intolerance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Roflumilast?
MediHelp rates the interaction as moderate. Fedratinib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can raise exposure to roflumilast and its active N-oxide metabolite. Higher exposure may increase PDE4-related adverse effects such as diarrhea, nausea, weight loss, insomnia, headache and psychiatric symptoms.
How serious is the interaction between Fedratinib and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal, weight, sleep and mood adverse effects of roflumilast during co-therapy. Consider stopping roflumilast if intolerance develops.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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