Drug interactions
Fedratinib + Sertraline
Severity: Minor
Fedratinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolised by CYP3A4 and CYP2C19, and it also inhibits CYP2D6, which contributes to sertraline metabolism. Sertraline is only a weak inhibitor of CYP3A4 and CYP2C19, so a clinically important rise in fedratinib is unlikely, though fedratinib may modestly raise sertraline levels.
What this interaction means in plain words
Fedratinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 and CYP2C19 by sertraline, and fedratinib inhibition of CYP2D6, may slightly alter exposure of either drug.
What to do
No empirical dose change is needed. Monitor for fedratinib gastrointestinal toxicity and for sertraline adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Sertraline?
MediHelp rates the interaction as minor. Fedratinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is metabolised by CYP3A4 and CYP2C19, and it also inhibits CYP2D6, which contributes to sertraline metabolism. Sertraline is only a weak inhibitor of CYP3A4 and CYP2C19, so a clinically important rise in fedratinib is unlikely, though fedratinib may modestly raise sertraline levels.
How serious is the interaction between Fedratinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for fedratinib gastrointestinal toxicity and for sertraline adverse effects.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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