Drug interactions
Fedratinib + Simvastatin
Severity: Major
Fedratinib and Simvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can raise plasma concentrations of simvastatin, a sensitive CYP3A4 substrate. Higher simvastatin exposure increases the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Fedratinib and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fedratinib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Fedratinib inhibits CYP3A4-mediated first-pass and hepatic metabolism of simvastatin.
What to do
Limit the simvastatin dose or switch to a statin not dependent on CYP3A4 such as rosuvastatin or pravastatin. Counsel the patient to report unexplained muscle pain and check CK if symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Simvastatin?
MediHelp rates the interaction as major. Fedratinib and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is a moderate CYP3A4 inhibitor and can raise plasma concentrations of simvastatin, a sensitive CYP3A4 substrate. Higher simvastatin exposure increases the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Fedratinib and Simvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the simvastatin dose or switch to a statin not dependent on CYP3A4 such as rosuvastatin or pravastatin. Counsel the patient to report unexplained muscle pain and check CK if symptoms occur.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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