Drug interactions
Fedratinib + Tamsulosin
Severity: Moderate
Fedratinib and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2D6, the two main enzymes that clear tamsulosin, so exposure may rise substantially. This increases the risk of hypotension, dizziness and syncope.
What this interaction means in plain words
Fedratinib and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Tamsulosin belongs to Genitourinary.
Why it happens
Fedratinib inhibits CYP3A4 and CYP2D6, reducing tamsulosin metabolism.
What to do
Monitor blood pressure and orthostatic symptoms, and counsel the patient about rising slowly. Reduce or hold tamsulosin if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Tamsulosin?
MediHelp rates the interaction as moderate. Fedratinib and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2D6, the two main enzymes that clear tamsulosin, so exposure may rise substantially. This increases the risk of hypotension, dizziness and syncope.
How serious is the interaction between Fedratinib and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and counsel the patient about rising slowly. Reduce or hold tamsulosin if symptomatic hypotension develops.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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