Drug interactions
Fedratinib + Ticagrelor
Severity: Moderate
Fedratinib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase ticagrelor exposure. This could increase bleeding risk and dyspnea.
What this interaction means in plain words
Fedratinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated ticagrelor metabolism by fedratinib.
What to do
Monitor for bleeding and ticagrelor adverse effects, including platelet counts since fedratinib may cause thrombocytopenia. Consider an alternative P2Y12 inhibitor if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Ticagrelor?
MediHelp rates the interaction as moderate. Fedratinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase ticagrelor exposure. This could increase bleeding risk and dyspnea.
How serious is the interaction between Fedratinib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and ticagrelor adverse effects, including platelet counts since fedratinib may cause thrombocytopenia. Consider an alternative P2Y12 inhibitor if bleeding occurs.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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