Drug interactions
Fedratinib + Tinidazole
Severity: Minor
Fedratinib and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase tinidazole exposure. Tinidazole adverse effects, including gastrointestinal and neurological symptoms, could be more likely.
What this interaction means in plain words
Fedratinib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4 by fedratinib reduces tinidazole clearance.
What to do
No dose adjustment is routinely required; monitor for tinidazole adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Tinidazole?
MediHelp rates the interaction as minor. Fedratinib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is a moderate CYP3A4 inhibitor and may increase tinidazole exposure. Tinidazole adverse effects, including gastrointestinal and neurological symptoms, could be more likely.
How serious is the interaction between Fedratinib and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required; monitor for tinidazole adverse effects.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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