Drug interactions
Fedratinib + Tranylcypromine
Severity: Moderate
Fedratinib and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine can inhibit CYP2C19 and, to a lesser extent, other CYP enzymes, so it may raise fedratinib exposure, which is cleared by CYP3A4 and CYP2C19. Higher fedratinib levels may increase toxicity such as GI effects, myelosuppression and the risk of encephalopathy including Wernicke's.
What this interaction means in plain words
Fedratinib and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Tranylcypromine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 (and possibly CYP3A4) by tranylcypromine may reduce fedratinib metabolism.
What to do
Consider an alternative to tranylcypromine where possible. If coadministered, monitor for fedratinib adverse effects and thiamine status, and reduce the fedratinib dose per labeling if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Tranylcypromine?
MediHelp rates the interaction as moderate. Fedratinib and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranylcypromine can inhibit CYP2C19 and, to a lesser extent, other CYP enzymes, so it may raise fedratinib exposure, which is cleared by CYP3A4 and CYP2C19. Higher fedratinib levels may increase toxicity such as GI effects, myelosuppression and the risk of encephalopathy including Wernicke's.
How serious is the interaction between Fedratinib and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to tranylcypromine where possible. If coadministered, monitor for fedratinib adverse effects and thiamine status, and reduce the fedratinib dose per labeling if needed.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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