Drug interactions
Fedratinib + Umeclidinium-vilanterol
Severity: Moderate
Fedratinib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may raise vilanterol exposure. This could increase tachycardia, tremor and hypokalemia from the beta-agonist.
What this interaction means in plain words
Fedratinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Fedratinib inhibits CYP3A4 and reduces vilanterol metabolism.
What to do
Monitor heart rate and potassium and watch for beta-agonist adverse effects. Consider an alternative bronchodilator if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Fedratinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may raise vilanterol exposure. This could increase tachycardia, tremor and hypokalemia from the beta-agonist.
How serious is the interaction between Fedratinib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and potassium and watch for beta-agonist adverse effects. Consider an alternative bronchodilator if symptoms emerge.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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