Drug interactions
Fedratinib + Valproic acid
Severity: Minor
Fedratinib and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4, CYP2C19 and CYP2D6, and valproate is only a weak inhibitor of some CYP enzymes. A meaningful rise in fedratinib exposure is unlikely, but fedratinib has important toxicities including GI effects and hepatotoxicity.
What this interaction means in plain words
Fedratinib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Possible weak inhibition of fedratinib metabolism by valproate; not well established.
What to do
No dose adjustment is expected. Monitor liver enzymes and GI tolerability, as both drugs can be hepatotoxic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Valproic acid?
MediHelp rates the interaction as minor. Fedratinib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is metabolized by CYP3A4, CYP2C19 and CYP2D6, and valproate is only a weak inhibitor of some CYP enzymes. A meaningful rise in fedratinib exposure is unlikely, but fedratinib has important toxicities including GI effects and hepatotoxicity.
How serious is the interaction between Fedratinib and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected. Monitor liver enzymes and GI tolerability, as both drugs can be hepatotoxic.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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