Drug interactions
Fedratinib + Zafirlukast
Severity: Moderate
Fedratinib and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is cleared by CYP3A4 and CYP2C19, and zafirlukast inhibits CYP3A4 and CYP2C9 weakly to moderately. Exposure to fedratinib may rise, increasing the risk of toxicity such as GI effects, myelosuppression and encephalopathy, but the combination has not been studied.
What this interaction means in plain words
Fedratinib and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast inhibition of CYP3A4 may reduce fedratinib metabolism; effect not formally studied.
What to do
Monitor blood counts and for fedratinib adverse effects, including neurologic symptoms and thiamine status; consider an alternative to zafirlukast such as montelukast if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Zafirlukast?
MediHelp rates the interaction as moderate. Fedratinib and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is cleared by CYP3A4 and CYP2C19, and zafirlukast inhibits CYP3A4 and CYP2C9 weakly to moderately. Exposure to fedratinib may rise, increasing the risk of toxicity such as GI effects, myelosuppression and encephalopathy, but the combination has not been studied.
How serious is the interaction between Fedratinib and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for fedratinib adverse effects, including neurologic symptoms and thiamine status; consider an alternative to zafirlukast such as montelukast if toxicity emerges.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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