Drug interactions
Felbamate + Fentanyl
Severity: Moderate
Felbamate and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate can cause somnolence and dizziness, which add to fentanyl's CNS depression. Felbamate also modestly induces CYP3A4, which may reduce fentanyl exposure.
What this interaction means in plain words
Felbamate and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with possible CYP3A4 induction by felbamate.
What to do
Monitor for sedation and for changes in analgesic effect, and adjust the fentanyl dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Fentanyl?
MediHelp rates the interaction as moderate. Felbamate and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate can cause somnolence and dizziness, which add to fentanyl's CNS depression. Felbamate also modestly induces CYP3A4, which may reduce fentanyl exposure.
How serious is the interaction between Felbamate and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for changes in analgesic effect, and adjust the fentanyl dose accordingly.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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