Drug interactions
Brexpiprazole + Felbamate
Severity: Moderate
Brexpiprazole and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate can cause somnolence and dizziness, which may add to brexpiprazole sedation. Felbamate also modestly induces CYP3A4, which could reduce brexpiprazole exposure.
What this interaction means in plain words
Brexpiprazole and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Felbamate belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible weak CYP3A4 induction by felbamate.
What to do
Monitor for sedation and for loss of psychiatric symptom control. Adjust the brexpiprazole dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Felbamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Brexpiprazole
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Brexpiprazole with Felbamate?
MediHelp rates the interaction as moderate. Brexpiprazole and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate can cause somnolence and dizziness, which may add to brexpiprazole sedation. Felbamate also modestly induces CYP3A4, which could reduce brexpiprazole exposure.
How serious is the interaction between Brexpiprazole and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for loss of psychiatric symptom control. Adjust the brexpiprazole dose according to clinical response.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
