Drug interactions
Felodipine + Idelalisib
Severity: Major
Felodipine and Idelalisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor, and felodipine is a highly CYP3A4-dependent substrate with extensive first-pass metabolism. Felodipine levels can increase markedly, leading to profound hypotension, reflex tachycardia and peripheral edema.
What this interaction means in plain words
Felodipine and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Felodipine belongs to Cardiovascular; Idelalisib belongs to Oncology.
Why it happens
Strong inhibition of intestinal and hepatic CYP3A4 by idelalisib reduces felodipine first-pass and systemic clearance.
What to do
Avoid the combination where possible and switch to a calcium channel blocker or antihypertensive less dependent on CYP3A4. If it must be used, start felodipine at the lowest dose and monitor blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Felodipine with Idelalisib?
MediHelp rates the interaction as major. Felodipine and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and felodipine is a highly CYP3A4-dependent substrate with extensive first-pass metabolism. Felodipine levels can increase markedly, leading to profound hypotension, reflex tachycardia and peripheral edema.
How serious is the interaction between Felodipine and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and switch to a calcium channel blocker or antihypertensive less dependent on CYP3A4. If it must be used, start felodipine at the lowest dose and monitor blood pressure closely.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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