Drug interactions
Felodipine + Melatonin
Severity: Minor
Felodipine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has been reported to raise blood pressure in patients treated with dihydropyridine calcium channel blockers. This may reduce the antihypertensive effect of felodipine.
What this interaction means in plain words
Felodipine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Proposed pharmacodynamic opposition; mechanism not firmly established.
What to do
Monitor blood pressure if melatonin is used regularly and adjust therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Felodipine with Melatonin?
MediHelp rates the interaction as minor. Felodipine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has been reported to raise blood pressure in patients treated with dihydropyridine calcium channel blockers. This may reduce the antihypertensive effect of felodipine.
How serious is the interaction between Felodipine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if melatonin is used regularly and adjust therapy if control worsens.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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