Drug interactions
Felodipine + Methylprednisolone
Severity: Minor
Felodipine and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may increase methylprednisolone exposure, while steroids may slightly reduce felodipine levels; the net effect is usually modest. Patients may experience altered blood pressure control or steroid adverse effects.
What this interaction means in plain words
Felodipine and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Methylprednisolone belongs to Endocrine.
Why it happens
Competition for CYP3A4 metabolism and P-glycoprotein efflux, with possible weak steroid-mediated induction.
What to do
Monitor blood pressure and steroid-related adverse effects; adjust doses only if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Methylprednisolone?
MediHelp rates the interaction as minor. Felodipine and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine may increase methylprednisolone exposure, while steroids may slightly reduce felodipine levels; the net effect is usually modest. Patients may experience altered blood pressure control or steroid adverse effects.
How serious is the interaction between Felodipine and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and steroid-related adverse effects; adjust doses only if clinically needed.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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