Drug interactions
Felodipine + Risperidone
Severity: Minor
Felodipine and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may modestly inhibit P-glycoprotein and raise risperidone exposure, but the clinical significance is uncertain. Both drugs can lower blood pressure, so additive orthostatic hypotension is the more practical concern.
What this interaction means in plain words
Felodipine and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Possible P-glycoprotein inhibition by felodipine plus additive hypotensive effects; the pharmacokinetic effect is not well established.
What to do
No routine dose change is needed. Monitor for orthostatic hypotension and sedation, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Felodipine with Risperidone?
MediHelp rates the interaction as minor. Felodipine and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine may modestly inhibit P-glycoprotein and raise risperidone exposure, but the clinical significance is uncertain. Both drugs can lower blood pressure, so additive orthostatic hypotension is the more practical concern.
How serious is the interaction between Felodipine and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for orthostatic hypotension and sedation, especially in older patients.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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