Drug interactions
Felodipine + Ruxolitinib
Severity: Minor
Felodipine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a weak CYP3A4 inhibitor and could slightly raise ruxolitinib exposure. A clinically important effect is unlikely.
What this interaction means in plain words
Felodipine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Ruxolitinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by felodipine slightly reduces ruxolitinib clearance.
What to do
No empirical dose change is needed. Monitor blood counts as usual for ruxolitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Felodipine with Ruxolitinib?
MediHelp rates the interaction as minor. Felodipine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine is a weak CYP3A4 inhibitor and could slightly raise ruxolitinib exposure. A clinically important effect is unlikely.
How serious is the interaction between Felodipine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor blood counts as usual for ruxolitinib.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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