Drug interactions
Felodipine + Temsirolimus
Severity: Moderate
Felodipine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors are associated with angioedema, and the risk appears higher when combined with calcium channel blockers. Swelling of the face, lips or airway could be serious.
What this interaction means in plain words
Felodipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
The mechanism is not well established; an additive predisposition to angioedema has been proposed.
What to do
Counsel patients to report swelling of the face, lips, tongue or throat promptly. Stop temsirolimus and treat if angioedema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Felodipine with Temsirolimus?
MediHelp rates the interaction as moderate. Felodipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. mTOR inhibitors are associated with angioedema, and the risk appears higher when combined with calcium channel blockers. Swelling of the face, lips or airway could be serious.
How serious is the interaction between Felodipine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the face, lips, tongue or throat promptly. Stop temsirolimus and treat if angioedema develops.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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