Drug interactions
Fenfluramine + Nalbuphine
Severity: Minor
Fenfluramine and Nalbuphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine can cause somnolence or fatigue in some patients, and nalbuphine may add to this. The interaction is poorly characterised and the net effect is uncertain.
What this interaction means in plain words
Fenfluramine and Nalbuphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenfluramine belongs to Central Nervous System; Nalbuphine belongs to Musculoskeletal.
Why it happens
No firmly established mechanism; possible additive or opposing CNS effects.
What to do
Monitor for drowsiness and adjust nalbuphine if sedation becomes problematic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Nalbuphine?
MediHelp rates the interaction as minor. Fenfluramine and Nalbuphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine can cause somnolence or fatigue in some patients, and nalbuphine may add to this. The interaction is poorly characterised and the net effect is uncertain.
How serious is the interaction between Fenfluramine and Nalbuphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and adjust nalbuphine if sedation becomes problematic.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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