Drug interactions
Fenfluramine + Quetiapine
Severity: Moderate
Fenfluramine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine acts via serotonin release and agonism at serotonin receptors, while quetiapine blocks several serotonin receptors, which may reduce fenfluramine's anticonvulsant effect. Additive effects on sedation and serotonergic toxicity are also conceivable.
What this interaction means in plain words
Fenfluramine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at serotonin receptors, with possible additive CNS effects.
What to do
Monitor seizure control and sedation when combined and watch for signs of serotonin toxicity. Adjust therapy based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Quetiapine?
MediHelp rates the interaction as moderate. Fenfluramine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine acts via serotonin release and agonism at serotonin receptors, while quetiapine blocks several serotonin receptors, which may reduce fenfluramine's anticonvulsant effect. Additive effects on sedation and serotonergic toxicity are also conceivable.
How serious is the interaction between Fenfluramine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation when combined and watch for signs of serotonin toxicity. Adjust therapy based on clinical response.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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