Drug interactions
Fenfluramine + Sertraline
Severity: Major
Fenfluramine and Sertraline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so using them together can precipitate serotonin syndrome, with agitation, tremor, hyperthermia, clonus and autonomic instability. Fenfluramine labeling warns about combination with other serotonergic drugs.
What this interaction means in plain words
Fenfluramine and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenfluramine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects: fenfluramine releases serotonin and sertraline blocks its reuptake.
What to do
Avoid the combination if possible; if needed, monitor closely for serotonin syndrome, especially after dose increases. Stop one or both drugs if symptoms develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Sertraline?
MediHelp rates the interaction as major. Fenfluramine and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs enhance serotonergic activity, so using them together can precipitate serotonin syndrome, with agitation, tremor, hyperthermia, clonus and autonomic instability. Fenfluramine labeling warns about combination with other serotonergic drugs.
How serious is the interaction between Fenfluramine and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if needed, monitor closely for serotonin syndrome, especially after dose increases. Stop one or both drugs if symptoms develop.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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