Drug interactions
Fenfluramine + Sumatriptan
Severity: Moderate
Fenfluramine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases serotonin release, and its labeling warns of serotonin syndrome when used with other serotonergic drugs such as triptans. Combined use could lead to agitation, autonomic instability and neuromuscular hyperactivity.
What this interaction means in plain words
Fenfluramine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from serotonin release and 5-HT1B/1D agonism.
What to do
Monitor for symptoms of serotonin syndrome, especially when starting or increasing doses. Discontinue the serotonergic drug and give supportive care if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Sumatriptan?
MediHelp rates the interaction as moderate. Fenfluramine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine increases serotonin release, and its labeling warns of serotonin syndrome when used with other serotonergic drugs such as triptans. Combined use could lead to agitation, autonomic instability and neuromuscular hyperactivity.
How serious is the interaction between Fenfluramine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of serotonin syndrome, especially when starting or increasing doses. Discontinue the serotonergic drug and give supportive care if it occurs.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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