Drug interactions
Fenfluramine + Thioridazine
Severity: Moderate
Fenfluramine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a serotonergic agent and may have cardiac effects, while thioridazine prolongs QT. A direct interaction is not well characterized, and CNS effects may partly oppose or add.
What this interaction means in plain words
Fenfluramine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Mechanism not established; possible additive cardiac and CNS pharmacodynamic effects.
What to do
Monitor ECG and electrolytes, and perform periodic echocardiographic monitoring as recommended for fenfluramine. Review the need for thioridazine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Thioridazine?
MediHelp rates the interaction as moderate. Fenfluramine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine is a serotonergic agent and may have cardiac effects, while thioridazine prolongs QT. A direct interaction is not well characterized, and CNS effects may partly oppose or add.
How serious is the interaction between Fenfluramine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and perform periodic echocardiographic monitoring as recommended for fenfluramine. Review the need for thioridazine.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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