Drug interactions
Fenfluramine + Ziprasidone
Severity: Moderate
Fenfluramine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine acts through serotonin release and receptor agonism, and ziprasidone is a potent serotonin 5-HT2 antagonist that may blunt its effect. Combined use may also cause altered sedation, and both drugs affect serotonergic pathways, with a theoretical risk of serotonin toxicity.
What this interaction means in plain words
Fenfluramine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at serotonin receptors with overlapping serotonergic effects.
What to do
Monitor seizure control and clinical response to fenfluramine, and watch for signs of serotonin toxicity. Also monitor echocardiograms per fenfluramine requirements.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Ziprasidone?
MediHelp rates the interaction as moderate. Fenfluramine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine acts through serotonin release and receptor agonism, and ziprasidone is a potent serotonin 5-HT2 antagonist that may blunt its effect. Combined use may also cause altered sedation, and both drugs affect serotonergic pathways, with a theoretical risk of serotonin toxicity.
How serious is the interaction between Fenfluramine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and clinical response to fenfluramine, and watch for signs of serotonin toxicity. Also monitor echocardiograms per fenfluramine requirements.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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