Drug interactions
Fenofibrate + Fosphenytoin
Severity: Minor
Fenofibrate and Fosphenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, an enzyme inducer, which could modestly lower fenofibrate exposure. Because fenofibrate is not predominantly CYP3A4-cleared, the clinical effect is probably small.
What this interaction means in plain words
Fenofibrate and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4 and glucuronidation enzymes, theoretically increasing fenofibric acid clearance.
What to do
Check the lipid profile after starting or stopping the anticonvulsant and adjust fenofibrate if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fenofibrate with Fosphenytoin?
MediHelp rates the interaction as minor. Fenofibrate and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosphenytoin is converted to phenytoin, an enzyme inducer, which could modestly lower fenofibrate exposure. Because fenofibrate is not predominantly CYP3A4-cleared, the clinical effect is probably small.
How serious is the interaction between Fenofibrate and Fosphenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the lipid profile after starting or stopping the anticonvulsant and adjust fenofibrate if the response is inadequate.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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